BIOM-41. IDENTIFICATION OF GLIOMA CELLS BY PROFILING SINGLE-CELL BIOPHYSICAL PROPERTIES THROUGH MULTICONSTRICTION MICROFLUIDIC CHANNELS

Abstract This study introduces a multicontraction microfluidic channel that can differentiate glioma cells from normal glio cells. As pass through successive constriction channels, the incremental velocity and varying size profiles of will be collected, reflecting their biophysical properties. The data high-dimensional variables were analyzed , including cell sizes, velocities, increments. prediction value is used to represent difference between two groups using established classification model variables. At same time, we prepared three primary tumor patients with different grades verify efficacy this method. results show in channel, diagnostic made properties well identify cells, which gives novel method for efficient identification circulating rapid pathological diagnosis.